HIV/AIDS
Genome distribution of HIV-1 dependent on viremia level
Published in AIDS Weekly, May 24th, 2004
"The localization of HIV-1 proviruses in compositional DNA fractions from 27 AIDS patients during the chronic phase of the disease with depletion of CD4+ and different levels of viremia" wrote scientists in France, showed the following:
"(1) At low viremia, proviruses are predominantly localized in the GC-richest isochores, which are characterized by an open chromatin structure; this result mimics findings on HIV-1 integration in early infected cells in culture,
"(2) At higher viremia, an increased distribution of proviruses in GC-poor isochores (which match the GC...
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Source: AIDS Weekly (2004-05-24)
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