HIV/AIDS

HIV-1 Tat protein stimulates synthesis of potentially neurotoxic molecules

Published in AIDS Weekly, May 24th, 2004

HIV-1 Tat protein stimulates the synthesis of potentially neurotoxic molecules.

"The human immunodeficiency virus type-1 (HIV-1) regulatory protein Tat is produced in the early phase of infection and is essential for virus replication. Together with other viral products, Tat has been implicated in the pathogenesis of HIV-1-associated dementia (HAD). As HIV-1 infection in the brain is very limited and macrophage/microglial cells are the only cellular type productively infected by the virus, it has been proposed that many of the viral neurotoxic effects are mediated by microglial products," wrote scientists in the journal Neurochemical Research.

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Source: AIDS Weekly (2004-05-24)

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