Antimicrobials

New compounds antifungal and anticancer but inactive against HIV-1 and bacteria

Published in AIDS Weekly, June 7th, 2004

New alpha-(N)-heterocyclichydrazones have antifungal and anticancer properties but are inactive against HIV-1 and bacteria.

According to recent research from Italy, "A series of 3- and 5-methylthiophene-2-carboxaldehyde alpha-(N)-heterocyclichydrazones were synthesized and submitted to an in vitro investigation of their anticancer, anti-HIV and antimicrobial activities."

"Some of the newly synthesized compounds were found to possess antiproliferative properties, whereas no anti-HIV activity was seen: the most active of the series was the derivative 2i, which exhibited turnout growth inhibition activity against all cell lines displaying...

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Source: AIDS Weekly (2004-06-07)

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