Pharmaceutical and Drug Development
Novel synthesis of protease inhibitors yield potent anti-HIV activity
Published in AIDS Weekly, June 7th, 2004
"Novel indium-mediated radical cyclization reactions of aliphatic iodoalkynes have been studied. Treatment of iodoalkynes with a catalytic amount of In (0.1 equiv) and I-2 (0.05 equiv) promotes atom-transfer 5-exo cyclization to give five-membered alkenyl iodides," investigators writing in the Journal of Organic Chemistry report.
"In contrast," R. Yanada and colleagues reported, "reaction with In (2 equiv) and I-2 (1 equiv) yields reductive 5-exo cyclization products via the same 5-exo cyclization. Both processes are most likely initiated by low-valent indium...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
Source: AIDS Weekly (2004-06-07)
More Articles from AIDS Weekly
- HIV/AIDS Research
Aldo-keto reductase family pathway generates HP1 from S-1360 - HIV/AIDS Research
Phlorotannins from brown alga E. cava inhibit HIV-1 RT and protease - HIV/AIDS Virology
HIV-1 viral load and infectivity reduced in presence of cellular prion protein - HIV/HCV Treatment
HCV therapy with IFN/RBV relatively safe in patients coinfected with HIV and HCV - AIDS
Scientists discover how AIDS opens cell doors - AIDS
Small study shows weekly cycles of anti-HIV drugs successful - More from this issue of AIDS Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
