Immunology
COX-2 inhibition and AT1 R blockade treatment for chronic nephropathy
Published in AIDS Weekly, June 14th, 2004
"Chronic renal injury can be mediated by angiotensin II (ANG II) and prostanoids through hemodynamic and inflammatory mechanisms and attenuated by individual suppression of these mediators. In rats with 5/6 renal ablation (Nx), we investigated 1) the intrarenal distribution of COX-2, ANG II, and the AT(1) receptor (AT1 R); 2) the renoprotective and antiinflammatory effects of an association between the AT1 R blocker, losartan (Los), and the gastric sparing anti-inflammatory nitroflurbiprofen (NOF)," researchers in Brazil report.
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Source: AIDS Weekly (2004-06-14)
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