HIV/AIDS
Ezrin/CD95 linkage key role regulating susceptibility to CD95-mediated apoptosis
Published in AIDS Weekly, June 21st, 2004
According to published research from Italy, "CD95(APO-1/Fas)-mediated apoptosis of bystander uninfected T cells exerts a major role in the HIV-1-mediated CD4+ T-cell depletion. HIV-1 gp120 has a key role in the induction of sensitivity of human lymphocytes to CD95-mediated apoptosis through its interaction with the CD4 receptor. Recently, we have shown the importance of CD95/ezrin/actin association in CD95-mediated apoptosis."
"In this study," reported F. Luciani and colleagues, "we explored the hypothesis that the gp120-mediated CD4 engagement could be involved...
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Source: AIDS Weekly (2004-06-21)
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