HIV/AIDS Research
Overexpression of Oct-1 or -2 has no effect on HIV-1 transcription in CD4 cells
Published in AIDS Weekly, June 21st, 2004
Investigators at the University of Pennsylvania "explored the binding of octamer (Oct) transcription factors to the HIV-1 long terminal repeat (LTR) by gel shift assays and showed none of the previously identified four potential Oct binding sites bound Oct-1 or Oct-2. Overexpression of Oct-1 or Oct-2 had no effect on HIV-1 LTR activity in transiently transfected primary human CD4 T cells."
"Next," reported M. Zhang and colleagues, "primary human CD4 T cells were co-transfected with a green fluorescent protein (GFP)-expression vector and an Oct-1 or Oct-2 expression...
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Source: AIDS Weekly (2004-06-21)
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