Virology

Dendritic cell-associated function impairment distinguish HCV and HIV infection

Published in AIDS Weekly, June 21st, 2004

Dendritic cell-associated function impairment distinguishes HCV and HIV infection.

"Impaired APC functions may play important roles in chronicity of hepatitis C virus (HCV) and HIV infections. To investigate the separate and combined effects of HCV and HIV infection on immature dendritic cells (DCs), we evaluated myeloid-derived DC (MDC) and plasmacytoid-derived DC (PDC) frequencies and functions, measured by Toll-like receptor ligand-induced IFN-alpha and IL-12, in healthy controls and subjects with chronic HCV, HIV, and HCV-HIV infection. To evaluate the relation between innate and adaptive immunity, we measured HCV-specific IFN-gamma-producing T cell frequency,"...

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Source: AIDS Weekly (2004-06-21)

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