HIV/AIDS Genetics
Mutations at position 184 of HIV-1 RT affect virus titer and viral DNA synthesis
Published in AIDS Weekly, June 28th, 2004
"Methionine at position 184 of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) was changed to valine, isoleucine, threonine, or alanine in an HIV-1-based vector. The vectors were analyzed for replication capacity and for resistance to the nucleoside analog 2',3'-dideoxy-3thiacytidine (3TC) using a single-cycle assay," investigators in the United States report.
"Viruses containing the valine or isoleucine mutations were highly resistant to 3TC and replicated almost as well as the wild-type virus. The virus containing the threonine mutation was...
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Source: AIDS Weekly (2004-06-28)
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