CD4+ and CD8+ T-cell CDR3 clonotype expansion do not correlate with SIV viremia

"The total number of circulating CD4+ and CD8+ T-cells undergoing clonal expansions following SIVmac251 infection was determined using a T-cell receptor Vbeta chain (TRBV) third complementarity-determining region (CDR3) DNA heteroduplex tracking assay (HTA). This assay measures the number of newly expanding T-cell clones but not their antigenic specificity," investigators in the United States report.

"Fewer expanding CD4+ (3-23 per animal) than CD8+ (18-37 per animal) clonotypes were observed during the acute phase of SIV infection. CD8+ T-cell expansions peaked at 4...

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