HIV/AIDS Research
Novel polysulfated galactose-derivatized dendrimers binding antagonists of HIV-1
Published in AIDS Weekly, July 5th, 2004
According to recent research from the United States, "Evidence indicates that galactosyl ceramide (GalCer) and its 3'-sulfated derivative, sulfatide (SGalCer), may act as alternate coreceptors for HIV-1 in CD4- cells. Glycosphingolipids (GSLs) may also be necessary for fusion of HIV-1 and host cell membranes."
"Using an enzyme-linked immunosorbent assay to determine which GSL was the best ligand for both recombinant and virus-associated gp120, we found that SGalCer was the best ligand for each rgp120 and HIV-1 isolate tested. Therefore," R.D. Kensinger and...
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Source: AIDS Weekly (2004-07-05)
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