HIV/AIDS Research

Potential protective effect of HLA DQB1*06 alleles on course of HIV disease

Published in AIDS Weekly, July 19th, 2004

There is a potential protective effect of HLA DQB1*06 alleles on the course of HIV disease.

According to a study from England, "Polymorphism amongst the human leucocyte antigen (HLA) class II genes could influence antigen presentation and the ability to control human immunodeficiency virus (HIV)-1 by modulating the virus specific CD4 immune response. To examine the effect of such polymorphisms on disease progression, we studied a cohort of 46 HIV-1 infected long-term non-progressors (LTNPs), 87 intermediate progressors (IPs) and 26 rapid progressors."

"Kaplan-Meier survival analysis of all patients in the cohort on time to a CD4 count less than 350...

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Source: AIDS Weekly (2004-07-19)

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