HIV/AIDS Research
TARTAR dimer therapeutic target for treatment of HIV-1 infection
Published in AIDS Weekly, July 19th, 2004
According to a study from Denmark, "The HIV-1 genome consists of two identical RNA strands that are linked together through non-covalent interactions. A major determinant for efficient dimerization of the two RNA strands is the interaction between palindromic sequences in the dimerization initiation site."
"We use an interplay of bioinformatics, biochemistry, and atomic force microscopy to describe another conserved palindrome in the trans-activation response element (TAR) that functions as a strong dimerization site when transiently exposed to the viral nucleocapsid...
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Source: AIDS Weekly (2004-07-19)
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