CD4+ regulatory T cells contribute to viral persistence

According to a study from the United States, "The establishment of viral persistence generally requires evasion of the host CD8+ T cell response. Here we describe a form of evasion wherein the CD8+ T cells are fully capable of recognizing their cognate antigen but their effector functions are suppressed by regulatory T cells."

"Virus-specific CD8+ T cells adoptively transferred into mice persistently infected with Friend virus proliferated and appeared activated, but failed to produce IFNgamma or reduce virus loads. Cotransfer experiments revealed that a subpopulation of CD4+ T cells from...

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