Published in AIDS Weekly, July 19th, 2004
According to a study from the United States, "The establishment of viral persistence generally requires evasion of the host CD8+ T cell response. Here we describe a form of evasion wherein the CD8+ T cells are fully capable of recognizing their cognate antigen but their effector functions are suppressed by regulatory T cells."
"Virus-specific CD8+ T cells adoptively transferred into mice persistently infected with Friend virus proliferated and appeared activated, but failed to produce IFNgamma or reduce virus loads. Cotransfer experiments revealed that a subpopulation of CD4+ T cells from...
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