HIV/AIDS Research
CpG oligodeoxynucleotides activate HIV replication in latently infected T cells
Published in AIDS Weekly, July 26th, 2004
"CpG oligodeoxynucleotides (CpG ODNs) stimulate immune cells via the Toll-like receptor 9 (TLR9). In this study, we have investigated the effects of CpG ODNs on latent human immunodeficiency virus (HIV) infection in human T cells," wrote researchers in Germany.
"Treatment of the latently infected T cell line ACH-2 with CpG ODNs 2006 or 2040 stimulated HIV replication, whereas no effects were evident when ODNs without the CpG motif were used.
"CpG-induced virus reactivation was blocked by chloroquine," C. Scheller and coworkers reported, "indicating...
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Source: AIDS Weekly (2004-07-26)
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