HIV/AIDS Research
Novel HIV inhibitors generated through hybridization of known ligands
Published in AIDS Weekly, July 26th, 2004
According to recent research published in the Journal of Medicinal Chemistry, "In this work we describe BREED, a method for the generation of novel inhibitors from structures of known ligands bound to a common target."
"The method is essentially an automation of the common medicinal chemistry practice of joining fragments of two known ligands to generate a new inhibitor. The ligand-bound target structures are overlaid, all overlapping bonds in all pairs of ligands are found, and the fragments on each side of each matching bond are swapped to generate the new...
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Source: AIDS Weekly (2004-07-26)
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