Retrovirology
Progenipoietin-1 increases plasmacytoid/myeloid dendritic cells in SIV-infection
Published in AIDS Weekly, July 26th, 2004
"As in HIV-1 infection in humans, SIVsm infection of rhesus macaques causes a slow progressive loss of CD4 T-cells followed by the onset of AIDS. In addition, there is a loss of dendritic cells (DC) in peripheral blood, peripheral lymphoid tissues, and the skin.
"Increasing the number of CD4 T cells and DC may be an important step in restoring immune competence and thus delay disease progression," researchers in the Netherlands report.
"Recently, progenipoietins (ProGP), a new family of chimeric Flt3 and G-CSF receptor agonists, were demonstrated...
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Source: AIDS Weekly (2004-07-26)
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