Antiretroviral Therapy
Styrylquinolines do not interfere with HIV entry but act before integration
Published in AIDS Weekly, August 2nd, 2004
According to a study from France, "We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of action of these molecules."
"We show that SQLs do not interfere with virus entry. In fact," wrote S. Bonnenfant and colleagues, "concentrations of up to 20 times the 50% inhibitory concentration did not inhibit cell-to-cell fusion or affect the interaction between GP120 and CD4 in vitro. Moreover, the pseudotype of the retrovirus envelope did not affect drug...
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Source: AIDS Weekly (2004-08-02)
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