HIV/AIDS Research
Diketo acid integrase inhibitor resistance impairs HIV-1 replication/integration
Published in AIDS Weekly, August 2nd, 2004
"The diketo acids are potent inhibitors of HIV integrase (IN). Mutations in IN, T66I, S153Y and M154I, as well as T66I-S153Y and T661-M154I double mutations, confer resistance to diketo acids (D.J. Hazuda et al., Science 287:646-650, 2000).
"The effects of these IN mutations on viral replication, enzymatic activity and susceptibility to other HIV inhibitors are reported herein," scientists from the United States report.
"By immunofluorescence assay and real-time PCR," wrote D.J. Lee and colleagues, "all mutant viruses demonstrated a modest delay...
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Source: AIDS Weekly (2004-08-02)
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