HIV/AIDS Therapy
NNRTI stereochemistry and regiochemistry profoundly affect anti-HIV activity
Published in AIDS Weekly, August 2nd, 2004
"Chiral derivatives of several substituted halopyridyl and thiazolyl PETT compounds were synthesized as non-nucleoside inhibitors of the reverse transcriptase (RT) enzyme of the human immunodeficiency virus (HIV- 1).
"Molecular modeling studies indicated that because of the asymmetric geometry of the non-nucleoside inhibitors (NNRTI) binding pocket, the 'R' stercoisomers would fit the NNRTI binding pocket of the HIV-1 RT much better than the corresponding 'S' stereoisomers, as reflected by their 104-fold...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
Source: AIDS Weekly (2004-08-02)
More Articles from AIDS Weekly
- Antiretroviral Therapy
Styrylquinolines do not interfere with HIV entry but act before integration - HIV/AIDS Research
Species-specific tropism determinants found in the HIV-1 capsid - HIV/AIDS Therapy
Subcutaneous IL-2 therapy maintains CD4 cell increases in HIV-1 infection - HIV/AIDS-Related Disease
BCL-6 mutations seen in HIV-related pulmonary lymphoproliferative disorders - HIV/AIDS-Related Disease
HAART increases survival of patients with HIV-associated Hodgkin disease - AIDS Therapy
Up-front cost for treating HIV-infected patient in Africa is US$30 per visit - More from this issue of AIDS Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
