Published in AIDS Weekly, August 2nd, 2004
"The formation of genomic RNA dimers during the retroviral life cycle is essential for optimal viral replication and infectivity. The sequences and RNA structures responsible for this interaction are located in the untranslated 5' leader RNA, along with other cis-acting signals. Dimer formation occurs by specific interaction between identical structural motifs," scientists writing in the journal Biochemistry report.
"It is believed that an initial kissing hairpin forms following self-recognition by autocomplementary RNA loops, leading to formation of...
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