Antiretroviral Therapy
Novel thia-DCK analogues inhibit HIV replication in vitro
Published in AIDS Weekly, August 16th, 2004
"Two 1-thia-DCK analogues (9a and 9b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes," researchers in the United States report.
"Compound 9a showed excellent anti-HIV activity with an EC50 value of 0.00012 mcM and therapeutic index of 1,408,000.
"Compound 9b was less active with EC50 and TI values of 3.11 mcM and 62.3, respectively," P. Xia and coauthors reported.
Xia concluded, "The bioassay results indicated that thia-DCK analogues merit attention as potential HIV-1 inhibitors."
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Source: AIDS Weekly (2004-08-16)
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