Biological Markers
DC-SIGN is a marker for dendritic cells and alternatively activated macrophages
Published in AIDS Weekly, August 16th, 2004
"Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is a type II C-type lectin that functions as an adhesion receptor and mediates binding and internalization of pathogens such as virus (human immunodeficiency virus, hepatitis C), bacteria (Mycobacterium), fungi, and parasites.
"DC-SIGN expression in vivo is primarily restricted to interstitial dendritic cells (DC) and certain tissue macrophages. We now report that leukemic THP-1 cells, widely used as a model for monocyte-macrophage differentiation, express...
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Source: AIDS Weekly (2004-08-16)
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