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Retrovirus

Hemophagocytic syndrome sign of transformation to adult T-cell leukemia/lymphoma

Published in AIDS Weekly, August 16th, 2004

Hemophagocytic syndrome is sign of transformation to adult T-cell leukemia/lymphoma.

"A 55-year-old Caribbean woman with a 6-year history of smoldering adult T-cell leukemia/lymphoma presented with clinical and biological symptoms of hemophagocytic syndrome. An extensive search for infectious diseases was negative.

"A lymph node biopsy showing large T-cell lymphoma (CD4-, CD25) and findings of high LDH count and severe lymphocytosis led to the diagnosis of acute adult T-cell leukemia/lymphoma," wrote investigators in France.

"Antiretroviral therapy combining zidovudine, lamivudine, and interferon-alpha was started," A. Aouba and...

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