Retrovirolgy
Fusion of first 54 amino acids of Vpu to Env results in virus maturation
Published in AIDS Weekly, August 23rd, 2004
According to a study recently published in the journal Virology, "Previous studies have shown that the gene coding for the Vpu protein of the human immunodeficiency virus type 1 (HIV-1) is 5' to the em gene, is in a different reading frame, and overlaps the em, by 90 nucleotides.
"In this study, we examined the processing of the Env protein as well as the maturation and infectivity of a virus (SHIVVpenv) in which a single nucleotide was removed at the vpu-env junction, fusing the first 162 bases of vpu to the env ORF."
"Pulse-chase analysis...
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Source: AIDS Weekly (2004-08-23)
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