Published in AIDS Weekly, August 30th, 2004
"The membrane fusion events which initiate human immunodeficiency virus type 1 (HIV-1) infection and promote cytopathic syncytium formation in infected cells commence with the binding of the HIV envelope glycoprotein (Env) to CD4 and an appropriate coreceptor.
"Here, we show that HIV Env-coreceptor interactions activate Rac-1 GTPase and stimulate the actin filament network reorganizations that are requisite components of the cell fusion process," investigators in the United States report.
"Disrupting actin filament dynamics with jasplakinolide or latrunculin...
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