HIV/AIDS Research
HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL
Published in AIDS Weekly, August 30th, 2004
"Human immunodeficiency virus-specific CD8+ T cells are highly sensitive to spontaneous and CD95/Fas-induced apoptosis, and this sensitivity may impair their ability to control HIV infection.
"To elucidate the mechanism behind this sensitivity, in this study we examined the levels of antiapoptotic molecules Bcl-2 and Bcl-xL in HIV-specific CD8+ T cells from HIV-infected individuals," scientists writing in the Journal of Immunology report.
"Bcl-2 expression was markedly decreased in HIV-specific CD8+ T cells compared with...
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Source: AIDS Weekly (2004-08-30)
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