HIV/AIDS Research
Purifying selection masks mutational flexibility of HIV-1 reverse transcriptase
Published in AIDS Weekly, August 30th, 2004
According to recent research published in the Journal of Biological Chemistry, "DNA and RNA polymerases share a core architecture composed of three structurally conserved motifs: A, B, and C.
"Although the amino acid sequences of these motifs are highly conserved between closely related organisms, variation across broader evolutionary distances suggests that only a few residues in each motif are indispensable for polymerase function."
"To test this, we constructed libraries of human immunodeficiency virus type-1 (HIV-1) containing random...
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Source: AIDS Weekly (2004-08-30)
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