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AIDS/HIV Vaccine

DNA prime-MVA boost HIV vaccine tailored for eastern and central Africa

Published in AIDS Weekly, August 30th, 2004

Researchers have developed a DNA prime-MVA boost HIV vaccine tailored for eastern and central Africa.

According to a study from England, "For the development of human immunodeficiency virus type 1 (HIV-1) vaccines, traditional approaches inducing virus-neutralizing antibodies have so far failed. Thus the effort is now focused on elicitation of cellular immunity. We are currently testing in clinical trials in the United Kingdom and East Africa a T-cell vaccine consisting of HIV-1 clade A Gag-derived immunogen HIVA delivered in a prime-boost regimen by a DNA plasmid and modified vaccinia virus Ankara (MVA)."

"Here, we describe engineering and...

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