Antiretroviral Therapy

Specific genotype correlates with high plasma efavirenz levels in HIV patients

Published in AIDS Weekly, September 13th, 2004

Specific genotype correlates with high plasma efavirenz levels in HIV patients on efavirenz-containing therapy.

According to a study from Japan, "Efavirenz (EFV) is metabolized by cytochrome P450 2136 (CYP2B6) in the liver. We analyzed the genotypes of CYP2B6 and their contribution to plasma EFV concentrations in 35 EFV-treated patients in the International Medical Center of Japan."

"The mean plasma EFV concentration of patients with CYP2R6 *6/*6 (Q172H and K262R) (25.4±7.5 mcM, ±SD, n=2) was significantly higher than that of patients with genotypes *6 heterozygote (9.9±3.3 mcM, n=10) or without alleles *6 (8.0±2.6 mcM,...

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Source: AIDS Weekly (2004-09-13)

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