Herpesvirus
HHV-8-GPCR involvement in KS pathogenesis elucidated
Published in AIDS Weekly, September 27th, 2004
According to a study from the United States, "HHV-8-GPCR is a chemokine-like receptor encoded by KSHV, the etiologic agent of KS. HHV-8-GPCR is constitutively active. Although it is homologous to mammalian CXCR2, it binds CXC and CC chemokines."
"Structure-function analysis showed that chemokines bind primarily to the amino terminus whereas signaling occurs in the absence of: the amino terminus, which is, therefore, not a tethered agonist.
"In in vitro systems," J.P. Couty and colleagues wrote, "HHV-8-GPCR signals via multiple transduction pathways including,...
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Source: AIDS Weekly (2004-09-27)
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