HIV/AIDS Research
HIV-1 Gag assembles to a capsid through the formation of the 60 S multimer
Published in AIDS Weekly, October 11th, 2004
According to a study from Japan, "Human immunodeficiency virus Gag protein self-assembles into spherical particles, and recent reports suggest the formation of assembly intermediates during the process. To understand the nature of such assembly intermediates along with the mechanism of Gag assembly, we employed expression in Escherichia coli and an in vitro assembly reaction."
"When E. coli expression was performed at 37 degrees C, Gag predominantly assembled to a high order of multimer, apparently equivalent to the virus-like particles obtained following Gag...
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Source: AIDS Weekly (2004-10-11)
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