HIV/AIDS Research
Human cytidine deaminase APOBEC3G is a broad antiviral enzyme
Published in AIDS Weekly, October 11th, 2004
"Human cytidine deaminase APOBEC3G and the virion infectivity factor (vif) of the human immunodeficiency virus (HIV) are a pair of antagonistic molecules.
"In the absence of vif, APOBEC3G induces a high rate of dC to dU mutations in the nascent reverse transcripts of HIV that leads to the degradation of the HIV genome.
HIV vif, on the other hand, can suppress the translation and trigger the degradation of human APOBEC3G," investigators in the United States report.
"We studied the rate of APOBEC3G gene evolution from five hominoids and two Old World...
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Source: AIDS Weekly (2004-10-11)
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