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HIV/AIDS Research

NRTIs have different effects on resting cells infected with HIV

Published in AIDS Weekly, October 11th, 2004

Nucleoside analog reverse transcriptase inhibitors have different effects on resting cells infected with HIV.

According to recent research from the United States, "We have previously described an in vitro model for the evaluation of the effects of different immunomodulatory agents and immunotoxins (ITs) on cells latently infected with human immunodeficiency virus (11][V).

"We demonstrated that latently infected, replication-competent cells can be generated in vitro after eliminating CD25+ cells with an IT. Thus, by selectively killing the productively infected cells with an anti-CD25 IT we can generate a population of latently infected cells."

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