Published in AIDS Weekly, October 18th, 2004
"We established small interfering RNA (siRNA) directed against poly(ADP-ribose) polymerase 1 (PARP-1) that effectively reduces the expression of PARP-1 in two human cell lines," scientists writing in the Journal of Virology report.
"Established siRNA against PARP-1 significantly suppressed human immunodeficiency virus type 1 (HIV-1) replication," said M. Kameoka and coworkers, "as well as the activation of the integrated HIV-1 long terminal repeat promoter."
"These results indicate that PARP-1 is required for efficient HIV-1 replication in human...
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