AIDS/HIV Vaccine
Pathogenic SHIVs and SIVs target different CD4+ T cell subsets
Published in AIDS Weekly, October 25th, 2004
According to published research from the United States, "In contrast to simian immunodeficiency viruses (SIVs), which induce immunodeficiency over a one- to three-year period, highly pathogenic simian-human immunodeficiency viruses (SHIVs) cause a complete, irreversible, and systemic depletion of CD4+ T lymphocytes in rhesus monkeys within weeks of infection. By using small-molecule competitors specific for CCR5 and CXCR4 in ex vivo assays, we found that highly pathogenic SHIVDH12R exclusively uses CXCR4 for infection of rhesus peripheral...
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Source: AIDS Weekly (2004-10-25)
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