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HIV/AIDS Vaccine
CCR5-targeted SIV vaccination strategy prevents or inhibits SIV
November 1st, 2004
CCR5-targeted SIV vaccination strategy prevented or inhibited SIV infection. "Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV We targeted the SIV CCR5 coreceptor in a combined CCR5-SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27," scientists in England report. "Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine," stated Willy M. J. M. Bogers at the Biomedical Research Primate Centre...
Source: AIDS Weekly (2004-11-01)
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