HIV/AIDS Research

Novel CCR5 mutation affects HIV co-receptor immunoreactivity/fusogenic property

Published in AIDS Weekly, November 8th, 2004

A novel CCR5 mutation affects HIV coreceptor immunoreactivity and fusogenic property.

According to recent research published in the journal AIDS, "A Nepalese heterozygous carrier of a CCR5 mutant, designated 118delF, was characterized."

"There was a 3 base pair deletion at 352-354 in the CCR5 open reading frame, resulting in the deletion of the phe-118 residue located in the third transmembrane domain.

"The mutant protein has retained antigen specificity near the third extracellular loop (ECL3)," X.Y. Zhao and coauthors reported, "but that of ECL2 is markedly reduced."

"The mutation has also abrogated...

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Source: AIDS Weekly (2004-11-08)

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