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AIDS Weekly

Susan Hasty, Publisher

Table of Contents . . . November 22nd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in AIDS Weekly | Other Publications

Antiretroviral Therapy - Antiretroviral CSF penetration improves cognitive disorders in HIV infection

HIV/AIDS Perinatal Transmission - Nevirapine does not prevent perinatal HIV-1 transmission in the field

HIV/AIDS Risk - Adolescent woman may be more susceptible to HIV infection than men in Cameroon

HIV/AIDS Therapy - HIV viral load after 4 weeks of HAART predicts virologic outcome at 24 weeks

JC Virus - PMA and IL-1beta dramatically increase JC virus transcription in glial cells

AIDS/HIV Diagnosis - OraQuick ADVANCE rapid HIV-1/2 antibody test is sensitive and specific

AIDS/HIV Vaccine - DNA vaccine elicits efficient CD8+ T cell response to HIV epitope

AIDS/HIV Vaccine - HIV-1 protease cleavage site in human C1-inhibitor identified

AIDS/HIV Vaccine - Parenteral vaccine adjuvants promote mucosal anti-HIV immune responses

AIDS/HIV Vaccine - Poxviruses expressing HIV protein stimulate cytotoxic T-cell responses

Anti-Infective Agents - Sulfamates offer promise as anti-infective/anticancer agents

Antiviral Drug Development - Rab9 identified as a novel antiviral drug target

Business & Finance - Biotechnology company receives $5 million financial commitment

Business & Finance - Pharmaceutical updates divestiture process, clinical development projects

Business Update - Company opens nucleic acid amplification testing laboratory

Cancer Research - Study sheds light on how poxviruses can jump from species to species

Cancer Therapy - Patent granted for production and processing of the reovirus

Diagnostics - Diagnostic kit maker receives approval to export Vscan test kits from China

Diagnostics - Diagnostics company donates rapid HIV tests in China

Disease Prevention - Malawi: Project encourages female condom use to prevent HIV transmission

Finance - Chronimed reports positive Q1 results; merger with MIM on track

Finance - Pharmaceutical company reports third quarter results

HIV/AIDS - Pediatric HIV/AIDS medical centers to be built in Africa

HIV/AIDS Epidemiology - Doctors Without Borders says children with HIV/AIDS dying needlessly

HIV/AIDS Drug Resistance - Incomplete HIV suppression may account for resistant mutations in brain

HIV/AIDS Education - HIV/AIDS knowledge lowest among Chinese college students from rural areas

HIV/AIDS Epidemiology - Use of blood donor data for HIV surveillance does not reflect normal population

HIV/AIDS Genetics - HIV-1 recombination is a major evolutionary force affecting genetic variation

HIV/AIDS Healthcare - Deaf gay men perceive HIV/AIDS healthcare providers as lacking in compassion

HIV/AIDS Pathogenesis - Non-syncytia-inducing HIV inhibits replication of syncytia-inducing strains

HIV/AIDS Prevention - Global communication effectively transfers HIV prevention strategies

HIV/AIDS Research - 2-Aminopurine fluorescence binding assay quantitates HIV-1 TAR interactions

HIV/AIDS Research - CD4 infection with infectious HIV-1 leads to IL-2 promoter hyper-responsiveness

HIV/AIDS Research - CD4+ cell loss in T-tropic HIV-1 infection is not directly mediated by apoptosis

HIV/AIDS Research - Conserved carboxy terminus of HIV-1 Gag important for virion assembly/release

HIV/AIDS Research - Cyoplasmic p53 may enhance the accuracy of HIV-1 RT DNA synthesis

HIV/AIDS Research - Determinants within gp120 and gp41 contribute to CD4 independence of SIV Env

HIV/AIDS Research - HIV-1 integration sites flanked by potential MARs can act as promoters

HIV/AIDS Research - HIV-infected CD8 lymphocytes generated through infection of activated CD8 cells

HIV/AIDS Research - Hsp70 protects cells from cell cycle arrest and apoptosis induced by HIV-1 Vpr

HIV/AIDS Research - IgMs selectively cleave HIV gp120 by a nucleophilic mechanism

HIV/AIDS Screening - HIV screening inadequate in North Carolina jails

HIV/AIDS Testing - British embassy in Zimbabwe denies racism, staff unrest

HIV/AIDS Therapy - Antiretroviral treatment decisions based on toxicity/resistance/convenience

HIV/AIDS Therapy - Each nucleoside/nucleotide backbone of HIV therapy has its advantages

HIV/AIDS Therapy - Genotypic HIV drug resistance in plasma may predict resistance in genital tract

HIV/AIDS Therapy - Improved activity of abacavir prodrug due to increased CBV-TP metabolites

HIV/AIDS Therapy - Mandela urges South Africans to participate in AIDS survey

HIV/AIDS Therapy - Marketing authorization application submitted for Tipranavir

HIV/AIDS Therapy - Mechanism elucidated for bleomycin inhibition of HIV-1

HIV/AIDS Therapy - NRTIs decrease mitrochondrial DNA synthesis and oxidative enzyme content

HIV/AIDS Therapy - Quality of life increased with enfuvirtide plus optimized background regimen

HIV/AIDS Therapy - Safety data should not be extrapolated from early to new HIV protease inhibitors

HIV/AIDS Transmssion - Woman gets jail time for violating HIV law

HIV/AIDS-Related Cardiology - Surgical drainage not justified in AIDS-related cardiac tamponade

HIV/AIDS-Related Depression - Nonadherence to HAART independently associated with depression

HIV/AIDS-Related Insulin Resistance - Indinavir increases glucose production in healthy HIV-uninfected men

HIV/AIDS-Related Mycobacterium - Mycobacterium avium complex infection in HIV infection rare in the era of HAART

HIV/AIDS-Related Nutrition - Nutrition management is complicated in HIV-infected persons

HIV/AIDS-Related Renal Disease - Increased prevalence of HIV-related end-stage renal disease is minimal

HIV/AIDS-Related Wasting Syndrome - Hyperphagia contributes to normal body composition in asymptomatic HIV infection

Healthcare Delivery - Performance incentives improve quality of TB/HIV healthcare delivery

Healthcare Disparities - Blacks get HIV medications later than whites

Hepatitis - Hepatitis study information presented at conference

Hepatitis B Virus - EMEA issues positive opinion on hepatitis B vaccine containing Corixa's MPL

Herpesvirus - E2F1/CDK2 promoter activation requires N- and C-terminal regions of KSHV LANA

Herpesvirus - Kaposi sarcoma-associated herpesvirus immediate early gene activity explored

Human Papillomavirus - Microscopy/RT-PCR identifies mechanisms of long-term HPV oral mucosal infection

Immunology - Subnormal immunity to measles in found in HIV+ mothers and infant cord blood

Information Technology - DRC wins $4.8M contract to support the U.S. Navy's HIV management system

Kaposi Sarcoma Herpesvirus - KSHV ORF36 protein kinase activates c-Jun N-terminal kinase signaling pathway

Kaposi Sarcoma-Related Herpesvirus - Poly(ADP-ribose) polymerase 1 binds to KSHV TR and modulates latency replication

Leukemia - Antiviral therapy for adult T cell leukemia lymphoma is promising

Mother-to-Child HIV Transmission - P-glycoprotein inhibitors plus indinavir might reduce vertical infection

Natural Products - HIV-1 inhibitory compounds isolated from Calophyllum brasiliense leaves

Pediatric Cancer - Nongenetic causes are most likely risk factors for childhood cancer development

Personnel - Yves Rosconie named president, CEO of Canadian endocrin-focused biopharm company

Pneumocystis Carinii Pneumonia - Enrollment completed for DB289 clinical trial in Pneumocystis carinii pneumonia

Quality of Life - Physically active HIV-infected persons have higher life satisfaction

Sexual & Reproductive Health - Rare sexually transmitted disease on rise in Netherlands

Sexual Dysfunction - Study finds high prevalence of sexual dysfunction in HIV+ women

Stem Cell Transplantation - Daily IV busulfan + cyclophosphamide for 4 days followed by SCT may be toxic

Tuberculosis -  Mycobacterium avium strains exhibit differential virulence

Type 2 Diabetes - Data demonstrate the potential of arimoclomol for the treatment of diabetes

Vaccine Development - License agreement reached for MedPulser DNA Delivery System in two applications

West Nile Virus - Diagnostics company announces clearance of diagnostic assay for West Nile Virus

World Population - United Nations report says world population could be 9 billion in 2300

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