HIV/AIDS Research
CD4 infection with infectious HIV-1 leads to IL-2 promoter hyper-responsiveness
Published in AIDS Weekly, November 22nd, 2004
According to a study from Canada, "A chronic state of immune hyperactivation is a feature of human immunodeficiency virus type-1 (HIV-1) infection.
"Studies on the molecular mechanisms by which HIV-1 can modulate the activation state of T cells indicate that both Nef and Tat can alter T cell activation. However, the vast majority of data has been obtained from experiments performed with vectors encoding a single virus protein."
"We demonstrate that infection of human CD4+ T lymphocytes with fully infectious HIV-1 leads to a...
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Source: AIDS Weekly (2004-11-22)
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