HIV/AIDS Research
IgMs selectively cleave HIV gp120 by a nucleophilic mechanism
Published in AIDS Weekly, November 22nd, 2004
Investigators in the United States report "the selective catalytic cleavage of the HIV coat protein gp120, a B cell superantigen, by IgM antibodies (Abs) from uninfected humans and mice that had not been previously exposed to gp120."
"The rate of IgM-catalyzed gp120 cleavage was greater than of other polypeptide substrates, including the bacterial superantigen protein A.
"The kinetic parameters of gp120 cleavage varied over a broad range depending on the source of the IgMs, and turnover numbers as great as 2.1/minute were observed, suggesting that different Abs possess...
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Source: AIDS Weekly (2004-11-22)
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