HIV/AIDS Therapy
NRTIs decrease mitrochondrial DNA synthesis and oxidative enzyme content
Published in AIDS Weekly, November 22nd, 2004
According to recent research from the United States, "Nucleoside reverse transcriptase inhibitors (NRTIs) have been hypothesized to inhibit mitochondrial DNA polymerase gamma, resulting in decreased mtDNA synthesis and mitochondrial insufficiency in HIV-1- infected patients. mtDNA synthesis was measured directly using a stable isotope mass spectrometric method following NRTI treatment in rodents."
"3'-Azido-3'-deoxythymidine (AZT) was added to water (1 mg/mL) and administered ad libitum to female Sprague-Dawley rats for 1-8 weeks (n=4 or 5...
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Source: AIDS Weekly (2004-11-22)
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