JC Virus
PMA and IL-1beta dramatically increase JC virus transcription in glial cells
Published in AIDS Weekly, November 22nd, 2004
"JC virus causes the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML) under immunosuppressive states such as AIDS. During the pathogenesis of AIDS, HIV-infected microglia secrete cytokines including interleukin-1 and tumor necrosis factor-alpha TNF-alpha), which affect neuronal cells resulting in dysfunction of the CNS.
"We hypothesized that extracellular stimuli released from HIV-infected microglia may reactivate JC virus by affecting neighboring oligodendrocytes," scientists in South Korea report.
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Source: AIDS Weekly (2004-11-22)
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