Published in AIDS Weekly, November 22nd, 2004
"JC virus causes the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML) under immunosuppressive states such as AIDS. During the pathogenesis of AIDS, HIV-infected microglia secrete cytokines including interleukin-1 and tumor necrosis factor-alpha TNF-alpha), which affect neuronal cells resulting in dysfunction of the CNS.
"We hypothesized that extracellular stimuli released from HIV-infected microglia may reactivate JC virus by affecting neighboring oligodendrocytes," scientists in South Korea report.
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