HIV/AIDS Therapy
Lopinivir efficacy decreases following cotransfection of wild-type HIV clones
Published in AIDS Weekly, November 29th, 2004
"The impact of cotransfection of mixtures of mutant and wild type (WT) virus on the observed phenotype and replication capacity (RC) in a single-cycle human immunodeficiency virus (HIV) phenotypic assay has been investigated by cotransfecting mutant HIV clones expressing the firefly luciferase expression gene with a WT clone expressing Renilla luciferase.
"Four mutant constructs with different genotypes displayed <1% RC when transfected alone. Cotransfection of as little as 9% of the WT clone resulted in an 18- to 33-fold increase in the RC of the mutant clones,"...
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Source: AIDS Weekly (2004-11-29)
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