AIDS/HIV Vaccine
HIV-1 Tat protein modulates generation of cytotoxic T cell epitopes
Published in AIDS Weekly, November 29th, 2004
According to a study from Italy, "Tat, the trans activation protein of HIV, is produced early upon infection to promote and expand HIV replication and transmission. However, Tat appears to also have effects on target cells, which may affect antigen recognition both during infection and after vaccination. In particular, Tat targets dendritic cells and induces their maturation and antigen-presenting functions, increasing Th1 T cell responses. We show in this work that Tat modifies the catalytic subunit composition of immunoproteasomes in B...
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Source: AIDS Weekly (2004-11-29)
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