HIV/AIDS-Related Dementia
Discreet species of gp41 high-MW aggregates present in HIV-related dementia
Published in AIDS Weekly, December 6th, 2004
According to investigators in the United States, "Accumulation of the HIV envelope protein gp41 is observed in the brain tissues of patients suffering from HIV-associated dementia."
"Previously, we have shown by electron microscopy that the extracellular domain of SIV gp41, which is analogous to that of HIV, forms high-molecular weight aggregates in vitro, and we have postulated that such high-molecular weight aggregates are responsible for neurological damage in a manner similar to protein deposition diseases such as Alzheimer's and the prion...
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Source: AIDS Weekly (2004-12-06)
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