HIV/AIDS Research
SI viruses may hasten disease progression by perturbing T cell homeostasis
Published in AIDS Weekly, December 13th, 2004
According to published research from the United States, "Loss of T cell homeostasis usually precedes the onset of AIDS. We hypothesized that rapid progressors may be transmitted with HIV-1 that is particularly able to perturb T cell homeostasis."
"To this end," E.G. Meissner and coworkers said, "we have tested two transmitted, syncytium-inducing (SI) viral isolates from a rapid progressor in two thymus models. One of the isolates (R3A) exhibited markedly rapid kinetics of replication and thymocyte depletion.
"These phenotypes mapped to the...
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Source: AIDS Weekly (2004-12-13)
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