Pneumocystis Carinii
SP-A is local effector molecule in lung host defense against P. carinii
Published in AIDS Weekly, December 13th, 2004
"Surfactant protein A (SP-A), a member of the collectin family, selectively binds to Pneumocystis carinii and mediates interactions between pathogen and host alveolar macrophages in vitro.
"To test the hypothesis that mice lacking SP-A have delayed clearance of Pneumocystis organisms and enhanced lung injury, wild-type C57BL/6 (WT) and SP-A-deficient mice (SP-A-/-) with or without selective CD4+-T-cell depletion were intratracheally inoculated with Pneumocystis organisms," investigators in the United States report.
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Source: AIDS Weekly (2004-12-13)
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