HIV/AIDS Research
Selected AA substitutions in C-terminal region of HIV-1 CA affect virus assembly
Published in AIDS Weekly, December 20th, 2004
According to a study from Sweden, "The capsid protein (CA or p24) of human immunodeficiency virus type 1 (HIV-1) plays a major role both early and late in the virus replication cycle.
"Many studies have suggested that the C-terminal domain of this protein is involved in dimerization and proper assembly of the viral core. Point mutations were introduced in two conserved sites of this region and their effects on viral protein expression, particle assembly and infectivity were studied."
"Eight different mutants (L205A...
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Source: AIDS Weekly (2004-12-20)
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