HIV/AIDS Therapy
HIV integrase inhibitors identified via phage display technique
Published in AIDS Weekly, January 3rd, 2005
"Human immunodeficiency virus type 1 integrase catalyzes the integration of proviral DNA into the infected cell genome, so it is an important potential target for antiviral drug design.
"In an attempt to search for peptides that specifically interact with integrase (IN) and inhibit its function, we used an in vitro selection procedure, the phage display technique. A phage display library of random heptapeptides was used to screen for potential peptide ligands of HIV-1 IN," scientists in France report.
"Several phage clones were identified that specifically...
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Source: AIDS Weekly (2005-01-03)
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